Table 5 Neuroradiological structure and WMH scores (Scheltens scale) of CD prior to treatment (baseline), after surgical remission and sex- and age-matched NFA subjects.

From: Detrimental effects of hypercortisolism on brain structure and related risk factors

 

NFA (n = 14)

CD baseline (n = 14)

CDin remission (n = 14)

P value CD baseline versus NFA

P value CD baseline versus in remission

Neuroradiological structure

Hippocampal height (mm)

8.61 ± 0.74

6.52 ± 0.92

6.98 ± 0.59

0.000

0.047

Width of temporal horn (mm)

2.41 ± 0.61

3.32 ± 0.87

3.13 ± 0.54

0.003

0.502

Uncotemporal index

0.1885 ± 0.0187

0.1962 ± 0.0219

0.2064 ± 0.0133

0.329

0.173

SFR

0.0184 ± 0.0039

0.0331 ± 0.0084

0.0320 ± 0.0151

0.000

0.736

FFR

0.0259 ± 0.0117

0.0321 ± 0.0089

0.0287 ± 0.0094

0.000

0.406

BFR

0.2851 ± 0.0125

0.3067 ± 0.0212

0.3052 ± 0.0198

0.004

0.678

BCR

0.0756 ± 0.0148

0.0889 ± 0.0173

0.0817 ± 0.0103

0.038

0.024

Third ventricle width (mm)

3.11 ± 0.81

4.95 ± 1.31

4.21 ± 1.09

0.000

0.002

WMH score (Scheltens scale)

Frontal lobe

0 (0)

0 (2.25)

0 (1.25)

0.058

0.257

Parietal lobe

0 (1)

0 (4)

0 (1)

0.034

0.027

Temporal lobe

0 (0)

0 (3.25)

0 (0.25)

0.042

0.042

Occipital lobe

0 (1)

0 (1.75)

0 (1)

0.168

0.084

Basal ganglia

0 (1)

0 (1.5)

0 (1)

0.121

0.461

Infratentorial region

0 (0)

0 (0)

0 (0)

0.180

0.180

DWMH

0.5 (2)

0.5 (16)

0 (6)

0.025

0.048

PVH

0 (2)

1 (7.25)

0 (3)

0.037

0.017