Figure 1

Adult and children with active tuberculosis exhibit substantial molecular degree of perturbation. (A,B) Left panels: Histograms show the single sample molecular degree of perturbation (MDP) score values relative to the healthy control group between adult and child (PTB pulmonary TB, EPTB extrapulmonary TB, HC healthy controls). MDP values were calculated as described in Methods. The Kruskal–Wallis test with Dunn’s multiple comparisons was used to compare MDP values between each clinical group. Right panels: Scatter plots of the summary data for each group are shown. MDP score values were compared between PTB or EPTB patients (C) or healthy controls (D) from Adult and Child. Lines in the scatter plots represent median values. Data were compared using the Mann–Whitney U test. *P < 0.05; **P < 0.01; ***P < 0.0001.