Figure 3

Network analysis of the MDP matrices in the study groups. (A,B) Spearman correlation matrices of the biomarker expression levels in each study group were built and Circos plots were used to illustrate the correlation networks. Each circle represents a different plasma parameter. The size of each circle is proportional to the number of significant correlations. P-values were adjusted for multiple measurements using Holm–Bonferroni’s method and the connecting lines represent statistically significant correlations (P < 0.003). Red connecting lines represent positive correlations while blue lines infer negative correlations. Color intensity is proportional to the strength of correlation (rho value). Node analysis was used to illustrate the number of significant correlations per marker. Markers were grouped according to the number of connections from minimum to maximum numbers detected.