Figure 3

(Top) Preliminary data results with model estimated biophysical parameters of diffusion, proliferation, and traction force and (bottom) conventional morphometric assessment methods. As previously described, parameters D₀, k, and λ were fit for each untreated and treated MCTS system over the time course. The model fit parameters are able to describe the underlying biophysics driving MCTS changes in response to paclitaxel treatment. The conventional morphometric assessment methods of core diameter and invasive diameter can describe overall growth, shrinkage, or stasis of MCTS, but are unable to infer mechanistic biophysical interpretation.