Figure 3 | Scientific Reports

Figure 3

From: The pharmaceutical solvent N-methyl-2-pyrollidone (NMP) attenuates inflammation through Krüppel-like factor 2 activation to reduce atherogenesis

Figure 3

NMP is bioactive in vivo. (a) Real-time PCR analysis in liver samples of mRNA expression of (a) Klf2 mRNA in mice treated with 25, 125 and 250 mg/kg of NMP. ***p < 0.001, **p < 0.005,*p < 0.01 by one-way ANOVA with Bonferroni’s multiple comparison test (n = 5 mice). Each data point denotes a liver sample from an individual mouse. (b,c) endogenous mouse Cxcl12 and Vcam-1 mRNA in treated mice with 25 mg/kg mouse. mRNA amounts are normalized to Gapdh mRNA relative to the level of liver samples in non-treated animals. (n = 5; ***p < 0.001, unpaired Student’s t test).

Back to article page