Table 2 Characteristics of acute PE patients with intermediate early mortality risk who died and survivors at 1-year follow-up.

From: Prothrombotic fibrin clot properties associated with NETs formation characterize acute pulmonary embolism patients with higher mortality risk

Variable

PE-related death (n = 9)

Survivors (n = 97)

P value

Age, years

68 [61–80]

58 [40–70]

0.032

Men, n (%)

4 (44.4)

49 (50.5)

0.73

Body-mass index, kg/m2

26 [23–30]

27 [24–31]

0.28

Characteristics of acute PE

Intermediate-low mortality risk, n (%)

2 (22.2)

75 (89.3)

0.0004

Intermediate-high mortality risk, n (%)

7 (77.8)

22 (26.2)

Right ventricular dysfunction, n (%)

8 (88.9)

38 (39.2)

0.004

Unprovoked PE, n (%)

7 (77.8)

64 (66)

0.47

Clinical characteristics, n (%)

Prior venous thromboembolism, n (%)

0

6 (6.2)

0.58

Coronary heart disease, n (%)

3 (33.3)

40 (41.2)

0.64

Prior myocardial infarction, n (%)

2 (22.2)

22 (22.7)

0.97

Prior stroke, n (%)

1 (11.1)

8 (8.2)

0.77

Hypertension, n (%)

3 (33.3)

56 (57.7)

0.16

Heart failure, n (%)

2 (22.2)

23 (23.7)

0.92

Diabetes mellitus, n (%)

3 (33.3)

33 (34)

0.97

Chronic obstructive pulmonary disease, n (%)

0

12 (12.4)

0.59

Laboratory investigations

Endogenous thrombin potential, nM × min

2088 [1765–2593]

1688 [1499–1943]

0.031

Citrullinated histone H3, ng/mL

4.49 [3.66–5.62]

3.1 [1.9–3.98]

0.038

Ks, × 10-9cm2

5.60 [4.90–5.91]

6.35 [5.45–7.2]

0.066

CLT, min

129 [115–149]

109 [99–124]

0.029

  1. Data are shown as numbers (%) or median [1st quartile-3rd quartile].
  2. Ks fibrin clot permeability, CLT clot lysis time.