Figure 1 | Scientific Reports

Figure 1

From: Impaired iloprost-induced platelet inhibition and phosphoproteome changes in patients with confirmed pseudohypoparathyroidism type Ia, linked to genetic mutations in GNAS

Figure 1

Changes in Gsα-mediated VASP phosphorylation in platelets from patients with suspected PHP Ia. Isolated, washed platelets were preincubated with iloprost (0–10 nM), fixed, permeabilised and stained with FITC anti-P-VASP mAb. (A) Representative flow cytometric histograms of VASP phosphorylation after iloprost treatment of platelets from control subject C1 and patient P1. (B) Quantified VASP phosphorylation results from control subjects (C1–12) and patients (P1–7). Box plots indicate medians ± interquartile ranges (whiskers represent 2.5–97.5th percentiles, n = 12).

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