Table 2 BA levels of hepatic tissues from C57BL/6J mice and gastric tissues of C57BL/6J, KM mice, SD rats, NZ white rabbits and JX black pigs (pmol/mg).

From: Increased levels of conjugated bile acids are associated with human bile reflux gastritis

Bile acid

Hepatic tissues of C57BL/6J mice (n = 8)

Gastric tissues of C57BL/6J mice (n = 8)

Gastric tissues of KM mice (n = 8)

Gastric tissues of SD rats (n = 6)

Gastric tissues of NZ white rabbits (n = 4)

Gastric issues of JX black pigs (n = 3)

CA

17.15 ± 3.38

48.91 ± 31.68

198.15 ± 74.62

11.69 ± 6.87

1.13 ± 0.52

0.07 ± 0.02

CDCA

4.73 ± 1.92

4.05 ± 3.04

3.95 ± 2.57

3.35 ± 2.99

0.05 ± 0.03

2.60 ± 0.37

a-MCA

9.94 ± 4.02

6.28 ± 5.35

7.15 ± 4.76

1.60 ± 0.87

0.06 ± 0.03

n.d

b-MCA

36.16 ± 13.69

34.57 ± 23.48

53.00 ± 20.19

4.55 ± 3.04

0.19 ± 0.21

0.02 ± 0.003

GCA

0.44 ± 0.04

0.21 ± 0.12

0.18 ± 0.10

0.70 ± 0.91

0.90 ± 1.10

 

GCDCA

n.d

0.05 ± 0.04

0.14 ± 0.03

0.16 ± 0.14

0.29 ± 0.43

0.24 ± 0.05

TCA

119.31 ± 36.64

24.07 ± 29.48

83.26 ± 46.49

8.26 ± 11.78

1.88 ± 1.44

n.d

TCDCA

7.18 ± 4.65

1.97 ± 3.66

1.60 ± 0.52

2.26 ± 2.34

0.07 ± 0.03

0.18 ± 0.03

Ta/b-MCA

2.8 ± 1.72

30.53 ± 32.31

48.53 ± 36.41

5.56 ± 9.51

1.29 ± 0.96

n.d

DCA

2.17 ± 0.87

32.86 ± 23.91

42.14 ± 14.73

4.23 ± 4.93

3.03 ± 2.82

n.d

LCA

0.22 ± 0.10

0.62 ± 0.42

1.49 ± 0.77

0.39 ± 0.29

0.10 ± 0.07

0.07 ± 0.01

UDCA

5.64 ± 1.26

3.94 ± 2.70

3.48 ± 0.95

2.86 ± 4.4

0.32 ± 0.27

n.d

12-ketoCDCA

n.d

0.75 ± 0.50

4.46 ± 2.49

0.76 ± 0.51

0.05 ± 0.03

1.14 ± 0.95

12-ketoLCA

n.d

3.82 ± 1.79

3.54 ± 2.32

0.80 ± 0.91

0.17 ± 0.10

n.d

3-ketoCA

n.d

0.5 ± 0.32

4.10 ± 4.57

0.10 ± 0.02

n.d

n.d

6-ketoLCA

0.34 ± 0.09

0.73 ± 0.53

0.93 ± 0.45

0.64 ± 0.37

0.01 ± 0.005

0.28 ± 0.12

7-ketoDCA

n.d

5.41 ± 3.19

31.14 ± 26.12

2.74 ± 1.83

0.10 ± 0.10

n.d

7-ketoLCA

n.d

n.d

0.82 ± 0.34

0.28 ± 0.13

n.d

0.08 ± 0.01

ACA

1.52 ± 0.78

3.06 ± 2.54

3.54 ± 2.43

n.d

n.d

n.d

apo-CA

0.33 ± 0.07

0.5 ± 0.36

0.47 ± 0.19

n.d

n.d

n.d

HCA

n.d

n.d

n.d

n.d

n.d

1.56 ± 0.85

HDCA

2.02 ± 0.6

5.06 ± 3.28

5.16 ± 3.24

4.97 ± 7.25

0.05 ± 0.01

2.68 ± 0.37

muro-CA

3.16 ± 1.24

2.71 ± 2.28

1.62 ± 1.43

0.84 ± 0.71

n.d

n.d

UCA

0.22 ± 0.09

0.39 ± 0.21

0.36 ± 0.16

0.07 ± 0.04

0.01 ± 0.02

n.d

w-MCA

16.66 ± 7.13

19.64 ± 14.74

39.5 ± 21.6

3.08 ± 2.89

0.07 ± 0.09

0.04 ± 0.01

GDCA

n.d

0.09 ± 0.10

0.12 ± 0.02

0.1 ± 0.04

2.65 ± 3.88

n.d

GLCA

n.d

0.02 ± 0.002

0.01 ± 0.001

0.01 ± 0.001

0.12 ± 0.20

n.d

GUDCA

0.09 ± 0.06

0.02 ± 0.01

0.04 ± 0.02

0.03 ± 0.02

0.02 ± 0.01

n.d

GHDCA

n.d

0.06 ± 0.02

0.07 ± 0.03

0.15 ± 0.12

0.01 ± 0.01

0.34 ± 0.11

TDCA

28.9 ± 16.44

6.04 ± 10.79

5.26 ± 4.10

0.52 ± 0.77

0.11 ± 0.03

n.d

TLCA

0.1 ± 0.05

0.09 ± 0.04

0.08 ± 0.02

n.d

0.01 ± 0.004

n.d

TUDCA

1.42 ± 1.15

2.03 ± 0.30

1.16 ± 0.64

0.33 ± 0.46

0.04 ± 0.03

n.d

THCA

n.d

n.d

n.d

n.d

n.d

0.11 ± 0.07

THDCA

1.25 ± 0.98

n.d

1.69 ± 0.72

0.97 ± 1.43

0.26 ± 0.19

0.15 ± 0.06

Tw-MCA

8.76 ± 9.84

21.53 ± 33.58

87.96 ± 48.96

n.d

n.d

n.d

  1. Data expressed as mean ± SEM; n.d.: not detected.
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