Figure 3

Correlation of CCSIT score with ¹⁸F-florbetaben, ¹⁸F-flortaucipir SUVR and cortical volume in all participants (a), and amyloid-β positive participants (b). We used Pearson’s correlation between the standardized residuals of CCSIT scores and regional SUVR values obtained with multiple linear regression model after adjusting for age, sex, years of education, presence of ApoE ε4 and total cognition scores. A covariate of intracranial volume was additionally adjusted for cortical volume. Horizontal bars represent P-values as − log₁₀ P. Red bars represent the regions that survived correction for region-wise multiple comparisons (false discovery rate-corrected P < 0.05), and blue dotted lines represent uncorrected P < 0.05. In the right side panel, brain regions showing highest significance in correlation with ¹⁸F-florbetaben, ¹⁸F-flortaucipir, and cortical volume are presented respectively. Blue dots represent CU participants, green dots represent MCI patients, and red dots represent DEM. Abbreviations: Aβ+ /− = Aβ-positivity, SUVR = standardized uptake value ratio, A = ¹⁸F-florbetaben SUVR, T = ¹⁸F-flortaucipir SUVR, N = cortical volume, SR = Standardized residual, CCSIT = Cross-Cultural Smell Identification Test, CU = cognitively unimpaired; MCI = mild cognitive impairment; DEM = dementia, ApoE = apolipoprotein E.