Table 2 Difference in methylation levels for triple negative breast cancer cases versus controls: matched analysis (analysis of variance), stratified by age (tertiles).

From: DNA methylation of the long intergenic noncoding RNA 299 gene in triple-negative breast cancer: results from a prospective study

 

Cases

Controls

Matched analysisa

Strata

n

Mean methylation level (SD)

n

Mean methylation level (SD)

P value

 

154

0.430 (0.051)

159

0.420 (0.051)

0.062

Age at diagnosis

26–52

50

0.453 (0.036)

51

0.423 (0.043)

0.0025

53–62

53

0.433 (0.044)

56

0.429 (0.053)

0.76

63+

51

0.404 (0.059)

52

0.405 (0.056)

0.94

Heterogeneity (df = 3)b

    

0.025

Age at blood draw

22–46

48

0.454 (0.036)

52

0.427 (0.042)

0.0010

47–58

59

0.429 (0.049)

58

0.422 (0.055)

0.46

59+

47

0.406 (0.056)

49

0.410 (0.057)

0.54

Heterogeneity (df = 3)b

    

0.0079

  1. SD standard deviation, df degrees of freedom.
  2. aControls matched on year of study entry, age at study entry, days blood in post before processing, and cancer-free years (time at risk).
  3. bHeterogeneity test: tests if the difference between cases and controls varies by age.
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