Figure 3 | Scientific Reports

Figure 3

From: Early modulation of macrophage ROS-PPARγ-NF-κB signalling by sonodynamic therapy attenuates neointimal hyperplasia in rabbits

Figure 3

ALA-SDT inhibits intimal hyperplasia in the rabbit femoral arteries at day 28 after treatment. (A) Representative cross-sections of OCT scanning and quantitative analysis of the mean lumen area and area stenosis in the indicated groups (n = 7). (B) Representative images of FFR and quantitative analysis of FFR values in the indicated group (n = 7). (C) Representative sections of HE staining and quantitative analysis of lumen area, intimal area, intima/media ratio, intima/IEL and EEL area in the indicated groups (n = 7). Each data point represents one rabbit. OCT optical coherence tomography, Baseline normal healthy rabbits, FFR fractional flow reserve, IEL internal elastic lamina, EEL external elastic lamina. Scale bar = 1 mm. *p < 0.05, **p < 0.01 and ***p < 0.001 versus control.

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