Figure 7 | Scientific Reports

Figure 7

From: Early modulation of macrophage ROS-PPARγ-NF-κB signalling by sonodynamic therapy attenuates neointimal hyperplasia in rabbits

Figure 7

ALA-SDT induces THP-1-derived macrophage apoptosis via PPARγ-NF-κB signalling. Cells were pre-treated with GW9662 for 1 h, followed by ALA-SDT treatment. (A) Western blot analysis of apoptosis-related proteins, including pro-caspase-9, cleaved caspase-9, pro-caspase-3, cleaved caspase-3, Bcl-2 and Bax. (B) THP-1-derived macrophages treated with ALA-SDT in the presence or absence of GW9662 were stained with Annexin V–FITC/PI, followed by flow cytometry analysis of apoptosis. **p < 0.01 and ***p < 0.001 versus control. ##p < 0.01 and ###p < 0.001 versus SDT.

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