Figure 3 | Scientific Reports

Figure 3

From: Increasing endogenous activity of NMDARs on GABAergic neurons increases inhibition, alters sensory processing and prevents noise-induced tinnitus

Figure 3

M-8324’s effect on trial to trial reliability and duration of sound evoked spiking. (A) Trial to trial reliability of sound evoked responses were not altered in the presence of 100 µM M-8324 (between 90 and 100 min after infusion), in both excitatory and inhibitory neurons. For excitatory neurons, N = 8 mice (vehicle), N = 6 mice (M-8324 30 µM), N = 9 mice (M-8324 100 µM). (B) A significant reduction in the duration of evoked responses in excitatory neurons by 100 µM M-8324. (C, D) Effect of M-8324 on spontaneous spiking (C, left) and sound-evoked spiking (C, right) in inhibitory neurons, spontaneous spiking (D, left) and sound-evoked spiking (D, right) in excitatory neurons. Dotted lines are of slope of 1 (no change). Data are presented as the mean ± SEM. * represent significance compared to vehicle group.

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