Figure 4
From: MAF1 is a chronic repressor of RNA polymerase III transcription in the mouse
Changes to the Pol II transcriptome in fed liver from Maf1−/− mice. (A) Representation of differentially expressed (DE, red) and unaffected (black) transcripts quantified by RNA-seq. The Venn diagram indicates the distribution of up- and down-regulated genes. (B) Relative reverse cumulative frequency plots are shown for the 937 differentially expressed genes in WT and Maf1−/− samples. A Kolmogorov–Smirnov test was performed using the WT sample as the reference. (C) MvA plot representing the mean of the scores (log2(counts)) obtained in the WT and Maf1−/− samples on the x-axis and the log2 fold change (Maf1−/−/WT) on the y-axis. Red and blue dots correspond to the set of 937 genes with adj. p values < 0.01 and fold change > log2 |0.5| (dotted blue lines). Orange symbols show ribosomal protein genes that were significantly (triangles) or not significantly (dots) changed.
