Figure 1

Phylogenetic analysis of the HA gene of H5 LPAIVs. (A) Maximum-likelihood phylogenetic tree of the HA genes of 48 H5 LPAIVs isolated in South Korea between 2010 and 2017 (red lines), along with all completed sequences (n = 5,283) of H5 genes of avian influenza viruses that were available in the using the NCBI Influenza Virus Database and GISAID. Evolutionary analyses were conducted in RAxML. (B) Maximum-likelihood phylogenetic tree of a subset of H5 genes belonging to the Eurasian lineage. The phylogenetic tree was generated in MEGA6. Bootstrap values (1,000 replicates) > 70% are displayed on the branch nodes. H5 LPAIVs isolated in South Korea from 2012 to 2017 are indicated by dots, and those isolated at other times are indicated by triangles. Sequences were acquired from GISAID and the NCBI Influenza Virus Database. HPAIV, highly pathogenic avian influenza virus; LPAIV, low pathogenic avian influenza virus.