Figure 4
From: A somatic evolutionary model of the dynamics of aneuploid cells during hematopoietic reconstitution
A model of factors influencing the strength of purifying selection in the post-radiation post-transplantation bone marrow. Early post-transplantation bone marrow is characterized by a highly perturbed microenvironment, as well as rapid HSC population expansion. This combination of factors reduces the strength of purifying selection and promotes drift. Later, HSC population numbers reach their maximum and the bone marrow microenvironment partially restores from radiation damage, processes that intensify the strength of purifying selection and lead to the elimination of aneuploid HSCs from the pool. The rapid cell division rates and the increased HSC population size (per se, excluding the effect of expansion) should act to suppress aneuploidy frequency.
