Table 1 Background levels of 1,2-NPQ- and 1,4-NPQ-derived Alb adducts in human serum derived from women with breast cancer and healthy controls.

From: Imbalances in the disposition of estrogen and naphthalene in breast cancer patients: a potential biomarker of breast cancer risk

Adducts

Patients (n = 143)

Healthy controls (n = 119)

1,2-NPQ-Alb (pmole/g-Alb)

Mean (SD)

210 (130)a

113 (51.9)

Median

178

102

Range

NDb–674

28.3–263

1,4-NPQ-Alb (pmole/g-Alb)

Mean (SD)

73.7 (52.3)

174 (108)a

Median

58.8

144

Range

NDb–397

46.2–674

Ratio of mean levels of 1,2-NPQ-Alb to 1,4-NPQ-Alb

2.85 (2.49)b

0.650 (0.480)

  1. a, Statistical significance, p < 0.001. b, Not detected. The limit of detection corresponds to 10 pmol/g for all adducts, assuming 10 mg protein was used for the assay.
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