Table 2 Ovary and uterus related adverse events with positive signals for statins as a class.
Classification | PTs | Proportional rate ratio (PRR) by age groups (years) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Overall | 0–18 | 19–39 | 40–59 | ≥ 60 | ||||||||||||
N | PRR | χ2 | N | PRR | χ2 | N | PRR | χ2 | N | PRR | χ2 | N | PRR | χ2 | ||
Ovarian cysts and neoplasms | Ovarian adenoma | 30 | 9.83 | 165.77 | – | – | – | – | – | – | – | – | – | 29 | 27.35 | 219.18 |
Cervix neoplasms | Adenocarcinoma of the cervix | – | – | – | – | – | – | – | – | – | 3 | 9.66 | 11.03 | – | – | – |
Cervix carcinoma stage III | – | – | – | – | – | – | – | – | – | 3 | 5.52 | 5.69 | – | – | – | |
Uterine disorders (excl neoplasms) | Endometrial hyperplasia | – | – | – | – | – | – | 3 | 8.40 | 12.22 | – | – | – | – | – | – |
Cervix disorders (excl neoplasms) | Cervix disorder | – | – | – | – | – | – | – | – | – | – | – | – | 4 | 7.01 | 9.30 |
Cervical incompetence | – | – | – | – | – | – | 3 | 4.50 | 4.90 | – | – | – | – | – | – | |
Endocrine disorders of gonadal function | Androgenetic alopecia | 21 | 13.25 | 149.00 | – | – | – | – | – | – | 12 | 17.18 | 99.86 | 7 | 14.31 | 33.62 |
Polycystic ovaries | – | – | – | – | – | – | 5 | 4.10 | 8.60 | – | – | – | – | – | – | |
Precocious puberty | – | – | – | 3 | 11.05 | 17.82 | – | – | – | – | – | – | – | – | – | |
Menstrual cycle and uterine bleeding disorders | Dysfunctional uterine bleeding | – | – | – | – | – | – | – | – | – | – | – | – | 4 | 4.91 | 6.12 |
Menopause related conditions | Menopausal symptoms | – | – | – | – | – | – | – | – | – | 35 | 2.73 | 32.97 | – | – | – |
Sexual function disorders | Dyspareunia | – | – | – | – | – | – | – | – | – | – | – | – | 7 | 4.29 | 10.59 |
Sexual dysfunction | – | – | – | – | – | – | – | – | – | – | – | – | 9 | 2.40 | 4.94 | |
Disturbance in sexual arousal | – | – | – | – | – | – | – | – | – | 6 | 3.44 | 7.05 | – | – | – | |
Orgasm abnormal | – | – | – | – | – | – | – | – | – | 4 | 4.91 | 7.32 | – | – | – | |
