Table 3 Ovary and uterus related adverse events with positive signals for atorvastatin.
Classification | PTs | Overall | 0–18 | 19–39 | 40–59 | ≥ 60 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N | PRR | χ2 | N | PRR | χ2 | N | PRR | χ2 | N | PRR | χ2 | N | PRR | χ2 | ||
Ovarian cysts and neoplasms | Ovarian cancer stage I | 4 | 7.25 | 14.01 | – | – | – | – | – | – | – | – | – | – | – | – |
Ovarian germ cell teratoma benign | 4 | 5.24 | 9.00 | – | – | – | – | – | – | – | – | – | – | – | – | |
Uterine disorders (excl neoplasms) | Endometrial disorder | 8 | 2.55 | 5.82 | – | – | – | – | – | – | – | – | – | 5 | 3.46 | 5.75 |
Adenomyosis | 9 | 2.33 | 5.34 | – | – | – | – | – | – | – | – | – | – | – | – | |
Endometriosis | – | – | – | – | – | – | 5 | 4.24 | 9.26 | – | – | – | 5 | 4.32 | 8.40 | |
Endocrine disorders of gonadal function | Androgenetic alopecia | 14 | 18.35 | 163.63 | – | – | – | – | – | – | 12 | 42.36 | 266.11 | – | – | – |
Blood testosterone increased | 9 | 3.36 | 11.97 | – | – | – | – | – | – | 5 | 11.77 | 32.85 | – | – | – | |
Menstrual cycle and uterine bleeding disorders | Uterine haemorrhage | – | – | – | – | – | – | – | – | – | – | – | – | 9 | 2.86 | 8.28 |
Menopause related conditions | Menopausal symptoms | – | – | – | – | – | – | – | – | – | 18 | 3.32 | 25.48 | – | – | – |
Sexual function disorders | Dyspareunia | – | – | – | – | – | – | – | – | – | 8 | 2.82 | 7.34 | 6 | 8.89 | 26.66 |
Sexual dysfunction | – | – | – | – | – | – | – | – | – | – | – | – | 8 | 5.30 | 20.20 | |
Anorgasmia | – | – | – | – | – | – | – | – | – | 8 | 3.20 | 9.48 | – | – | – | |
