Figure 4
The effects of KG3P and nepetin on airway immune cell number and neutrophilic airway inflammation in CFD-induced airway inflammation murine model. (A) Total BALF cells from each treatment group. (B) Total lung cells from each treatment group. For A&B, cells were counted using a haemocytometer. (C) Photomicrograph of BALF cytospins from mice with CFD-induced airway inflammation (magnification, ×200), (a) BALB/c normal Wild type control (WT), (b) CFD-sensitized control mice (CTL), (c) 10 mg/kg montelukast-treated CFD-sensitized mice, (d) 200 mg/kg KG3P-treated CFD-sensitized mice, (e) 100 mg/kg KG3P-treated CFD-sensitized mice, and (f) 20 mg/kg nepetin-treated CFD-sensitized mice. (D) KG3P and nepetin suppressed neutrophilia in BALF. Data are from individual mice, with arithmetic mean points shown in histograms. Values in bar graphs are expressed as mean ± SEM (n = 8 mice). #p < 0.05, ##p < 0.01, and ###p < 0.001 (compared to WT), and *p < 0.05, **p < 0.01, and ***p < 0.001 (compared to CTL).
