Table 2 Reported strategies of antibiotics in the perioperative period.
Study | Study groups | Pre- and peri-operative antibiotic | Post-operative antibiotic | Infection rate | p |
|---|---|---|---|---|---|
Lindeboom et al. (2003)29 | 1 dose regimen 4 doses regimen | Clindamycin 600 mg intravenously (IV), 15 min preoperatively Clindamycin 600 mg intravenously, 15 min preoperatively | Saline solution intravenously, every 6 h for 24 h Clindamycin 600 mg intravenously, every 6 h for 24 h | 5.71% (2/35) 2.9% (1/35) | p > 0.05 |
Barrier et al. (2009)3 | 1 dose group | Amoxicillin 1 g intravenously 30 mn preoperatively and every 2 h perioperatively | none | 7.0% (10/143) | |
Chow et al. (2007)17 | Penicillin and non penicillin antibiotics prophylaxis | none | 7.4% (96/1,294) | ||
Ghantous et al. (2019)28 | Intervention group | Amoxi-clav 1 g perioperatively | 0.09% NaCl, 50 mL, every 8 h for 5 days Amoxi-clav 1 g, every 8 h for 5 days | 2.5% (1/40) 0% (0/38) | p = 0.10 |
Tan et al. (2011)23 | Oral group Intraveinous group | Ampicillin 1 g intravenously, and 500 mg every 6 h | Amoxicillin 500 mg every 8 h + NaCl every 6 h during 2 days. Then amoxicillin 500 mg every 8 h during 3 days Ampicillin 1 g every 6 h + oral lactose every 8 h during 2 days. Then amoxicillin 500 mg every 8 h during 3 days | 14.1% (3/21) 28.6% (6/21) | p = 0.45 |
Zijderveld et al. (1999)20 | Intervention group Comparison group | Amoxicillin clavulanate 2200 mg intravenously (30 mn preoperatively) OR cefuroxime 1,500 mg i.v. (30 min preoperatively) 0.9% sodium chloride i.v. (30 min preoperatively) | 11–18% 53% | p < 0.004 | |
Ruggles et al. (1984)33 | Short term antibiotherapy Long-term antibiotherapy | Procaine penicillin 600.00 U and penicillin G 400,000 U intravenously 1 h preoperatively; penicillin G 2 g every 30 min perioperatively | Penicillin G 2 g 3 h Postoperatively Penicillin G 2 g every 6 h for 5 days | 15% (3/20) 0% (0/20) | |
Baqain et al. (2004)34 | Short-term antibiotherapy Long-term antibiotherapy | Amoxicillin 1 mg intravenously at induction or Clindamycin 300 mg intravenously at induction | Amoxicillin 500 mg or clindamycin 150 mg 3 h postoperatively Amoxicillin 500 mg every 8 h or clindamycin 150 mg every 6 h for 5 days | 23.5% (4/17) 11.7% (2/17) | p > 0.05 |
