Figure 7
From: Exploiting phage receptor binding proteins to enable endolysins to kill Gram-negative bacteria
Alignment of E. coli BL21 FhuA with homologous proteins of E. coli resistant to third-generation cephalosporins. E. coli BL21 FhuA (WP_000124402.1) was aligned to either FhuA or Ferrichrome Iron Receptors (FIR) of ESBL-producing E. coli strains (702: FIR (ESC_RA7174AA_AS_04180); 708: FIR (ESC_RA7666AA_AS_01170); 723: FhuA (ESC_RA7193AA_AS_00052); 724: FhuA (ESC_RA7194AA_AS_03122); 728: FhuA (ESC_RA7198AA_AS_01051); 770: FIR (ESC_RA7701AA_AS_01976)). Amino acids are colored based on the level of conservation with transition from light to dark grey to represent increasing conservation. Conservation with no threshold was used when we used the Jalview sequence alignment tool. The box highlights the alignment in the region responsible for the formation of the surface-exposed part of loop L4 in E. coli BL21.
