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Figure 1

From: Modulating electrophysiology of motor neural networks via optogenetic stimulation during neurogenesis and synaptogenesis

Figure 1

Approach to training mESC-derived motor neuronal embryoid body networks during neurogenesis and synaptogenesis. a Representative diagram of experimental setup combining differentiating ChR2 mESC’s and MEAs. b Representative diagram of ChR2 mESC differentiation toward motor neuronal embryoid bodies monitored by the expression of GFP guided by the motor neuronal specific Hb9 promoter (scale bar: 200 µm). c Representative image of fabricated MEA chip. d Representative spontaneous spike trains from MEA recordings of cultured embryoid body networks.

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