Figure 6
Stimulation during neurogenesis alters response to stimulation during network formation. Summed spike counts per each 100 ms for all active electrodes across the 20 min of recording were graphed for D11 and D25 for one representative sample from NS:S (a) and S:S (b). c. Zoom-in of a for 1 min, centered around the 20 s of stimulation at D25 for sample NS:S, the arrows represent the firing rate interval prior to stimulation (FRpre), the firing rate during stimulation (FRstim) and the firing rate after stimulation (FRpost). d. Bar graphs showing the mean firing rate increase between Frstim/Frpre for D11-D25. (n = 9; error bar represents SEM, *p < 0.05, ANOVA with Tukey post-hoc test)). e. Bar graphs showing the firing rate increase between Frpost/Frpre for D11-D25. (n = 9: error bar represents SEM, *p < 0.05, ANOVA with Tukey post-hoc test)). f. Raster plot of average correlation value for each electrode during 10 s bins across the entire recording time. g. Ratio of average correlation value prior to stimulation during recording and correlation value post stimulation (χpost/ χpre). (n = 3; error bar represents SEM, *p < 0.05, ANOVA with Tukey post-hoc test).
