Table 4 Summary of aggregation propensity and activities of KL peptides of length 6–18 amino acids, measured at constant peptide mass.

From: Phosphate-dependent aggregation of [KL]n peptides affects their membranolytic activity

Aggregation in PB (pH 7) or water (pH 10)

KL6 << KL10 < KL14 < KL18

Aggregation in presence of lipids

KL6 << KL10 < KL14 < KL18

Antimicrobial activity (with phosphate)

KL6 << KL10 >> KL14 ≈ KL18

Antimicrobial activity (reduced phosphate exposure)

KL6 << KL10 > KL14 > KL18

Hemolysis (no initial phosphate)

KL6 << KL10 < KL14 < KL18

Vesicle leakage (with PB)

KL6 << KL10 > KL14 < KL18

Vesicle leakage (no phosphate)

KL6 << KL10 ≈ KL14 ≈ KL18

  1. In bold print are shown the straightforward correlations between length and activity, once phosphate-induced aggregation artefacts have been eliminated.
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