Table 2 Characteristics and perinatal outcomes of pregnancies with CIUE.

Age—year

Median [interquartile range]

32 [28–36]

Age ≥ 35 y—no. (%)

37 (30.3)

BMI at first trimester†

Median [interquartile range]

22 [20–25]

BMI ≥ 30—no. (%)

10 (8.2)

Primigravida—no. (%)

23 (18.9)

Method of conception—no. (%)

In vitro fertilization

3 (2.5)

Ovulation induction or artificial insemination

4 (3.3)

Spontaneous

115 (94.2)

Pregnancy ≥ 22 WGA—no./total no. (%)

93/122 (76.2)

Gestational diabetes mellitus

10/93 (10.8)

Gestational hypertension

5/93 (5.4)

Preeclampsia

8/93 (8.6)

Preterm labor

9/93 (9.7)

Premature preterm rupture of membranes

10/93 (10.8)

Prenatal hospitalization

73/93 (78.5)

Fetal sex ratio M/F

1.02

Biological characteristics

no./total no. (%)

Abnormal alkaline phosphatase ≥ 22 WGA^¥—no./total no. (%)

36/59 (61.0)

Significant antinuclear antibodies^‡—no./total no. (%)

10/73 (13.7)

Positive antiphospholipid antibodies—no./total no. (%)

6/71 (8.5)

Lupus anticoagulant

3/71 (4.2)

Anti-cardiolipin

1/71 (1.4)

Lupus anticoagulant and anti-β2glycoprotein-I

2/71 (2.8)

Obstetrical outcomes

N = 122

Miscarriage—no. (%)

17 (13.9)

Week of gestation—mean ± SD

8 ± 2

Repeated miscarriage^§—no./total no. (%)

7/17 (41.2)

Stillbirth^†—no. (%)

17 (13.9)

Week of gestation—mean ± SD

22 ± 6

FGR^£—no./total no. (%)

14/15 (93.3)

< 3^rd percentile

12/14 (85.6)

Termination of pregnancy—no. (%)

18 (14.8)

Week of gestation—mean ± SD

24 ± 3

FGR^£—no./total no. (%)

17/17 (100)

< 3rd percentile

16/17 (94.1)

Live birth—no. (%)

70 (57.4)

FGR^£—no./total no. (%)

50/69 (72.5)

< 3rd percentile

36/50 (72.0)

Prematurity—no./total no. (%)

38/70 (54.3)

 < 28 WGA

2/38 (5.3)

[28 – 31⁺⁶ WGA]

9/38 (23.7)

[32—33⁺⁶ WGA]

6/38 (15.8)

[34—36⁺⁶ WGA]

21/38 (55.3)

Neonatal death no./total no. (%)

4/70 (5.7)

Live birth without comorbidity

7/70 (10.0)