Table 3 Comparison of EFS and OS between different clinical and molecular characteristic groups in NRAS^mut AML.

Variables	OS		EFS
Variables	χ2	P value	χ2	P value
Gender (female vs. male)	0.000	0.985	0.020	0.888
Age (≥ 60 vs. < 60 years)	36.959	0.000	30.844	0.000
AML types (non-M3 vs. M3)	4.709	0.030	6.949	0.008
NRAS type (mix vs. Q61 vs. G12/G13)	2.133	0.348	2.049	0.359
NRAS VAF (≥ 15% vs. < 15%)	0.071	0.790	0.000	0.991
WBC counts (≥ 100 vs. < 100 × 10⁹/L)	0.343	0.558	1.558	0.212
HGB counts (≥ 110 vs. < 110 g/L)	0.148	0.700	0.032	0.857
PLT counts (≥ 100 vs. < 100 × 10⁹/L)	1.197	0.274	1.992	0.158
BM blasts (≥ 80% vs. < 80%)	0.567	0.451	0.683	0.408
PB blasts (≥ 20% vs. < 20%)	0.872	0.350	0.430	0.512
Risk group (high vs. inter vs. low -risk)	12.549	0.002	10.029	0.007
Allo-HSCT (yes vs.no)	5.777	0.016	10.808	0.001
ETO (positive vs. negative)	1.753	0.185	1.337	0.248
MYH11-CBFβ (positive vs. negative)	0.300	0.584	0.352	0.553
Number of co-mutations (≥ 3 vs. < 3)	2.433	0.118	5.055	0.025
TET2 (mutated vs. wild type)	0.325	0.569	0.593	0.441
ASXL1(mutated vs. wild type)	3.625	0.057	1.048	0.306
NPM1 (mutated vs. wild type)	1.009	0.315	0.280	0.596
CEBPA (mutated vs. wild type)	1.982	0.159	0.187	0.666
DNMT3A (mutated vs. wild type)	0.233	0.629	0.022	0.881
FLT3-ITD (positive vs. negative)	0.220	0.639	1.142	0.285
KIT (mutated vs. wild type)	1.804	0.179	0.631	0.427
IDH2 (mutated vs. wild type)	0.090	0.764	4.095	0.043
RUNX1 (mutated vs. wild type)	6.075	0.014	3.407	0.065
U2AF1 (mutated vs. wild type)	18.556	0.000	15.464	0.000
SF3B1 (mutated vs. wild type)	4.578	0.032	2.511	0.113

VAF Variant allele frequency, WBC white blood cell, HGB hemoglobin, PLT platelets, BM bone marrow, PB peripheral blood, allo-HSCT allogenic hematopoietic stem cell transplantation.

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