Table 3 Unadjusted and adjusted competing risk regression of CSS and Cox-hazard proportional regression of OS and DFS with DM and other co-variates in STS patients.

From: Diabetes mellitus is independently associated with adverse clinical outcome in soft tissue sarcoma patients

Variables

CSS

OS

DFS

Unadjusted competing risk regression

Adjusted competing risk regression

Unadjusted Cox proportional regression

Adjusted Cox proportional regression

Unadjusted Cox proportional regression

Adjusted Cox proportional regression

SHR (95% CI)

P

aSHR (95% CI)

P

HR (95% CI)

P

aHR (95% CI)

P

HR (95% CI)

P

aHR (95% CI)

P

Diabetes

No

1

 

1

 

1

 

1

 

1

 

1

 

Yes

2.14 (1.18–3.90)

0.013

2.33 (1.21–4.49)

0.012

2.05 (1.28–3.28)

0.003

1.96 (1.17–3.28)

0.010

1.55 (0.90–2.66)

0.113

1.52 (0.86–2.67)

0.149

Age

< 40 years

1

 

1

 

1

 

1

 

1

 

1

 

40–59 years

0.78 (0.38–1.57)

0.486

0.92 (0.42–2.02)

0.843

0.86 (0.45–1.63)

0.637

1.24 (0.60–2.58)

0.554

1.14 (0.58–2.24)

0.699

1.30 (0.63–2.66)

0.479

≥ 60 years

1.07 (0.57–2.00)

0.842

1.19 (0.54–2.59)

0.665

1.84 (1.05–3.24)

0.034

2.17 (1.10–4.28)

0.025

1.89 (1.03–3.48)

0.040

1.63 (0.81–3.29)

0.172

Sex

Male

1

 

1

 

1

 

1

 

1

 

1

 

Female

0.69 (0.84–1.09)

0.113

0.67 (0.42–1.09)

0.110

0.91 (0.64–1.28)

0.577

0.94 (0.65–1.37)

0.747

0.86 (0.60–1.24)

0.429

0.96 (0.66–1.41)

0.854

Tumor size (cm)

1.02 (0.99–1.05)

0.137

1.02 (0.98–1.05)

0.314

1.02 (0.99–1.05)

0.075

1.03 (0.99–1.06)

0.092

1.04 (1.01–1.06)

0.005

1.03 (1.01–1.07)

0.027

Tumor depth

Superficial

1

 

1

 

1

 

1

 

1

 

1

 

Deep

1.23 (0.72–2.11)

0.448

1.54 (0.81–2.91)

0.186

0.85 (0.56–1.29)

0.442

0.92 (0.58–1.47)

0.739

1.10 (0.71–1.70)

0.663

0.93 (0.57–1.51)

0.774

Deep + superficial

1.75 (0.86–3.57)

0.123

2.05 (0.97–4.36)

0.060

1.74 (1.04–2.90)

0.035

1.71 (0.97–3.02)

0.065

1.68 (0.95–2.96)

0.076

1.38 (0.75–2.53)

0.293

Tumor grading

G1 + G2

1

 

1

 

1

 

1

 

1

 

1

 

G3

2.07 (1.28–3.34)

0.003

2.24 (1.21–4.15)

0.010

2.29 (1.55–3.40)

< 0.001

2.22 (1.41–3.49)

0.001

2.59 (1.69–3.96)

< 0.001

2.57 (1.58–4.18)

< 0.001

Resection margins

R0

1

 

1

 

1

 

1

 

1

 

1

 

R1

0.66 (0.15–2.92)

0.582

0.63 (0.13–2.95)

0.559

1.03 (0.42–2.51)

0.956

0.75 (0.30–1.91)

0.550

1.65 (0.77–3.55)

0.197

1.05 (0.41–2.65)

0.927

Adj. radiation

No

1

 

1

 

1

 

1

 

1

 

1

 

Yes

1.11 (0.70–1.76)

0.663

0.86 (0.52–1.43)

0.563

1.02 (0.70–1.46)

0.932

0.80 (0.54–1.18)

0.260

1.15 (0.79–1.68)

0.454

0.68 (0.60–1.38)

0.668

Adj. chemotherapy

No

1

 

1

 

1

 

1

 

1

 

1

 

Yes

1.55 (0.92–2.62)

0.097

1.55 (0.77–3.11)

0.220

1.09 (0.68–1.77)

0.711

1.47 (0.84–2.57)

0.178

1.46 (0.90–2.36)

0.126

1.47 (0.82–2.65)

0.198

  1. Adj Adjuvant, CI Confidence Interval, CSS Cancer Specific Survival, OS Overall Survival, DFS Disease-free Survival, HR Hazard Ratio, SHR Sub-hazard Ratio, aSHR Adjusted Sub-hazard Ratio.
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