Table 1 Summary of pilot screening results obtained with the HTS assay. Mean Z' factor ± SD.
Library Name | Number of compounds | Mean Z’ factor | Total hits | False positives | DNA intercalators | True positives |
|---|---|---|---|---|---|---|
Pfizer licensed compound library (manual) | 94 | 0.82 ± 0.08 | 1 | 0 | Doxorubicin | 0 |
Prestwick chemical library | 1273 | 0.58 ± 0.09 | 41 | 36 | Doxorubicin Epirubicin Propidium iodide Daunorubicin | Rabeprazole |
Protein–Protein interaction library | 5398 | 0.36 ± 0.09 | 48 | 48 | 0 | 0 |
Chemical diversity library | 7649 (50,000)a | 0.44 ± 0.08 | 82 | 82 | 0 | 0 |
Natural product collection | 2603 | 0.36 ± 0.14 | 26 | 26 | 0 | 0 |
Maybridge library | 13,974 | 0.33 ± 0.13 | 65 | 62 | 0 | KM 04550 KM 04416 JFD 02731 |
