Figure 2 | Scientific Reports

Figure 2

From: iPSC-derived progenitor stromal cells provide new insights into aberrant musculoskeletal development and resistance to cancer in down syndrome

Figure 2

Characterization of progenitor stromal cells. (a) Heatmap showing mesoderm-related gene expression correlation among isogenic clones 4C4-dMPs and 4C4-tMPs. The microarray expression data has been log-transformed. (b) Heatmap showing endothelium-related gene expression correlation among isogenic clones isoDS-iECs and DS-iECs. The microarray expression data has been log-transformed. (c) Statistically significant, mesoderm-specific functional processes identified using STRING database. Observed genes refer to the microarray gene set, and the background genes comprise all genes involved in the biological process. (d) Statistically significant, endothelial-specific functional processes identified using STRING database. Observed genes refer to the microarray gene set, and the background genes comprise all genes involved in the biological process. (e) Interaction network for 200 most down-regulated genes in 4C4-tMPs, constructed using STRING database (confidence score = 0.700). The gene cluster contains genes related to myogenic development. (f) Interaction network for 200 most down-regulated genes in DS-iECs, constructed using STRING database (confidence score = 0.700). The gene cluster contains genes related to stimulus response, migration, and inflammatory response.

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