Figure 2
From: Rod function deficit in retained photoreceptors of patients with class B Rhodopsin mutations
Slowly progressive thinning of photoreceptor outer nuclear layer (ONL) over a decade. (A, D) OCT scans along the vertical meridian crossing the fovea obtained at two ages separated by a decade or more in a younger (A) and older (D) subject. Insets, ultra-wide near-infrared autofluorescence imaging of the melanin-related pigments distinguishing darker retinal regions of demelanization and degeneration from the healthier regions with high signal levels. Arrows, location of the cross-sectional OCT scans shown. (B, C, E, F) ONL thickness at two ages (B, E) and their difference (C, F) as a function of retinal eccentricity. Dashed lines correspond to the expected variability, and orange sections of traces in panels (C) and (F) demarcate significant ONL changes. (G) ONL thinning rate across the cohort with long-term serial data as a function of eccentricity along the vertical meridian in retinal coordinates. The measured mean thinning rate (solid line) is smaller than the predicted rate (dashed) estimated from the mean rod vision loss.
