Figure 3
From: Rod function deficit in retained photoreceptors of patients with class B Rhodopsin mutations
Disease progression over a short interval of 2 years. (A, B) ONL thickness (A) and RSL values (B) as a function of eccentricity along the vertical meridian in a representative patient obtained over 2 years shows little change that is distinguishable beyond variability. (C, D) Estimated ONL thinning (C) and RSL progression (D) rates as a function of eccentricity along the vertical meridian in inferior and superior retinas of a cohort of patients with serial data obtained over a 2 year interval. Linear regression results are shown with solid lines. (E, F) ONL thinning (E) and RSL progression (F) rates as a function of distance from transition zone (TZ) in the superior and inferior retinas. Error bars represent ± 1.96 SD to illustrate the population distribution. *Indicates locations with significantly different than zero mean rates. Inset, a representative OCT scan showing the superior and inferior TZ locations (yellow vertical lines).
