Figure 7
From: Immune network dysregulation precedes clinical diagnosis of asthma
Regulatory communities of transcription factors (TFs) exhibit significant clustering based on binding distances within differentially methylated regions (DMRs). The genes on the X axis represent all DMRs from the Reese et al. meta-analysis of CBMCs, which demonstrated perturbation of expression from tetanus toxoid (TT) stimulation. The green dot represents the mean silhouette score (SS) calculated from the binding location distance matrix with TF regulatory clusters. The gold points and density plots represent the null distribution of mean SS from each of 10,000 permutations of the regulatory cluster labels. Asterisks represent statistical significance *p < 0.05; **p < 0.01; ***p < 0.001.
