Figure 3 | Scientific Reports

Figure 3

From: A rationally designed bicyclic peptide remodels Aβ42 aggregation in vitro and reduces its toxicity in a worm model of Alzheimer’s disease

Figure 3

DesBP modifies the aggregation process of Aβ42. (a) Normalised kinetic profiles of Aβ42 aggregation under quiescent conditions at a concentration of 2 μM in the absence and presence of various concentrations of DesBP, represented by different colors. (b) Average half-time of the aggregation at decreasing [Aβ42]:[DesBP] ratios. (c) Average maximum ThT fluorescence intensity of the aggregation at decreasing [Aβ42]:[DesBP] ratios. In (b, c), the error bars represent the standard deviation over 5 replicates.

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