Figure 6

DesBP restores the motility in a C. elegans model of Aβ42-mediated toxicity. (a) Fingerprint of the measurements of the effect of increasing concentration of DesBP, from 0 μM (red), to 10 μM (green), 20 μM (yellow) and 40 μM (orange) on the motility of the GMC1010 worm model of Alzheimer’s disease used in this work; N2 worms treated with lipid vesicles (blue) and with DesBP (Fig. S12, green) were used as controls. The fitness of the worms was measured by 5 different readouts: the fraction of worms alive at the end of the experiments (live ratio), the average number of body bends per minute (BPM), the average speed of movement (speed), the average amplitude of the bend motion (Bend Measure), and the average distance traveled per bend (Dist per bend). (b) The five fitness parameters in panel a were combined in an overall fitness parameter (total fitness) of the worms⁷⁸ in the presence and absence of DesBP.