Figure 5
From: CD122-targetted IL-2 signals cause acute and selective apoptosis of B cells in Peyer’s Patches
S4B6 IL-2C induce temporary loss of multiple B cell subsets in PPs. (A) Representative staining for IgD and IgM on B cells in PPs isolated from mice treated with either 3 consecutive treatments of S4B6 IL-2C or PBS. Summary analysis from 10 mice per group is shown for the number of B cells expressing the stated combinations of IgD and IgM in PPs. Mice were treated with S4B6 IL-2C or PBS for 3 days as in (A) but were analyzed 14 days after the final treatment. (B) The total number of CD45+ cells is shown for 3 mice per group in the spleen and PPs as well as (C) the total number of B cells in the spleen and PPs (*P < 0.05, **P < 0.005, NS denotes no significant difference).
