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Figure 2

From: Fatty acid mimetic PBI-4547 restores metabolic homeostasis via GPR84 in mice with non-alcoholic fatty liver disease

Figure 2

PBI-4547 improves serum parameters and insulin resistance in HFD mice. (A) Average body weight of STD, HFD and HFD + PBI-4547 mice. (B) Oral Glucose Tolerance Test (OGTT) and corresponding area under the curve after 4 weeks of treatment. (C) Average fasting blood glucose of the mice over 6 weeks of treatment.(D) Insulin resistance (HOMA-IR) and glucose disposition index of mice after 4 weeks of treatment. (E) Quantification of serum parameters: Insulin, adiponectin, triglycerides and total cholesterol in serum of mice after 0, 2 and 4 weeks of treatment. Data are presented as mean ± SEM (n ≥ 6 per group, one-way ANOVA with Dunnett’s multicomparison test vs HFD group). See also Fig. S1.

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