Figure 2 | Scientific Reports

Figure 2

From: Altered mechanisms of genital development identified through integration of DNA methylation and genomic measures in hypospadias

Figure 2

DNA methylation associated with characteristics of hypospadias in genic regions involved in beta-catenin signaling. The x-axis corresponds to genomic position within a chromosome and the y-axis plots − log10 p-values for three sources of statistical testing: (1) a scatter plot for the epigenome-wide association study (EWAS) where the top-associated CpG is indicated by a central vertical line, (2) a single red diamond at the top-associated CpG for two-stage least squares regression Mendelian randomization (2SLS MR) for causal relationship with hypospadias, and (3) horizontal lines across the length of gene transcripts for their causal association with hypospadias where multiple lines represent each tissue type in GTEx. Gene names above the plotted transcripts indicate Wald MR P < 0.05 and gene names below the plotted transcripts indicate Wald MR P > 0.05. Graph was generated by the authors using R version 3.5.2 (https://www.R-project.org/)15.

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