Table 1 Mutations detected in genes associated with drug resistance across the 151 M.tb isolates included in the study.
From: Genomic epidemiology of Mycobacterium tuberculosis in Santa Catarina, Southern Brazil
Resistant strain | n | Related resistance mutations | |
|---|---|---|---|
Isoniazid | 6 (4.0%) | 4 | katG Ser315Thr |
1 | fabG1 −15C>T | ||
1 | fabG1 −8T>C | ||
1 | ahpC −48G>A | ||
Rifampicin | 3 (2.0%) | 1 | rpoB Ser441Leu |
2 | rpoB Ser450Leu | ||
Pyrazinamide | 1 (0.7%) | 1 | pncA Val139Met |
Ethambutol | 1 (0.7%) | 1 | embB Met306Val |
Ethionamide | 2 (1.3%) | 1 | fabG1 −15C>T |
1 | fabG1 −8T>C | ||
Streptomycin | 2 (1.3%) | 2 | rpsL Lys43Arg |
Fluoroquinolones | 2 (1.3%) | 1 | gyrA Asp94Tyr |
1 | gyrA Ala90Val |
