Figure 1 | Scientific Reports

Figure 1

From: Correlative study of epigenetic regulation of tumor microenvironment in spindle cell melanomas and cutaneous malignant peripheral nerve sheath tumors

Figure 1

Histomorphology of C-MPNST and SCM cases in the cohort. (a,b) Representative photomicrographs of C-MPNST. (a) Lower power magnification showing a very cellular spindle cell neoplasm growing in fascicles (10× Objective Magnification). (b) Higher power magnification of the C-MPNST showing highly atypical spindle cells with mitotic activity depicted by the arrows (20× Objective Magnification). (c,d) Representative photomicrographs of SCM. (c) Tumor showing spindle cell morphology growing in fascicles with intervening sclerotic stroma invading in the subcutaneous tissue with associated lymphocytic infiltrate at the tumor edges (10× Objective Magnification). (d) Higher power magnification showing spindle cells with hyperchromatic nuclei and prominent cytologic atypia (20× Objective Magnification). Mitotic figures are noted too (depicted by the arrows). Immunostains for SOX10 and S100 are shown for C-MPNST (e,f) and SCM (g,h), respectively (20× Objective Magnification). Note the diffuse pattern of both SOX10 (nuclear) and S100 (nuclear and cytoplasmic) immunoreactivity in SCM, and the patchy SOX10 (nuclear) and S100 (nuclear and cytoplasmic) immunoreactivity in C-MPNST.

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