Figure 2 | Scientific Reports

Figure 2

From: Correlative study of epigenetic regulation of tumor microenvironment in spindle cell melanomas and cutaneous malignant peripheral nerve sheath tumors

Figure 2

Comparison of differential gene expression (DGE) between C-MPNST and SCM. (a) Adjusted DGE of 60 marker genes defining 14 cell types in the TME, and (b) JAK/STAT signaling pathway. DGE highlights important effectors/downstream signaling pathways in C-MPNSTs and SCMs. The values are represented in normalized log2FC ratios (cutoff > 0) with an adjusted FDR < 0.01. Red color denotes C-MPNST group and blue color the SCM group. (c) Corresponding GSEA analysis showing upregulation of “RA pathway” signatures in C-MPNST vs. SCM. ES, enrichment score; NES, normalized ES; FDR, false discovery rate.

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