Figure 5 | Scientific Reports

Figure 5

From: Correlative study of epigenetic regulation of tumor microenvironment in spindle cell melanomas and cutaneous malignant peripheral nerve sheath tumors

Figure 5

MethylCIBERSORT analysis was used to determine the TME composition across C-MPNST and SCM. (a) Color coded box plot representation of the different cell populations showing significant difference with middle line = median value; lower line = lower 25th percentile; upper line = upper 75th percentile; vertical line—confidence interval and points as outlier values. Note the significant enrichment (p < 0.05; Kruskal–Wallis test for comparison). (b) Summary of the different TME composition in each of the studied cases in the cohort. The x-axis is for the case number; y-axis  is the relative ratio of the specific color-coded population to the overall TME populations using MethylCIBERSORT. (c) Representation of the statistically significant populations enriched in the C-MPNST and SCM groups.

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