Table 1 Summary of the marker genes and immune cells in the TME.

From: Correlative study of epigenetic regulation of tumor microenvironment in spindle cell melanomas and cutaneous malignant peripheral nerve sheath tumors

Cell type

Selected marker genes

B cells

BLK, CD19, FCRL2, MS4A1, KIAA0125, TNFRSF17, TCL1A, SPIB, PNOC

CD45+ cells

PTRPC

Cytotoxic cells

PRF1, GZMA, GZMB, NKG7, GZMH, KLRK1

Dendritic cells

KLRB1, KLRD1, CTSW, GNLY, CCL13, CD209, HSD11B1

Exhausted CD8+ cells

LAG3, CD244, EOMES, PTGER4

Macrophages

CD68, CD84, CD163, MS4A4A

Mast cells

TPSB2, TPCAB1, CPA3, MS4A2, HDC

Neutrophils

FPR1, SIGLEC5, CSF3R, FCAR, FCGR3B, CEACAM3, S100A12

NK CD56dim cells

KIR2DL3, KIR2DL1, KIR2DL2, IL21R

NK cells

XCL1, XCL2, NCR1

T cells

CD6, CD3D, CD3E, SH3E, SH2D1A, TRAT1, CD3G

Th1 cells

TBX21

Tregs

FOXP3

CD8+ T cells

CD8A, CD8B

  1. NK natural killer; Th1 type 1T helper; Tregs regulatory T cells.
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