Table 1 Baseline characteristics.

From: Prognostic value of neutrophil-to-lymphocyte ratio in human epidermal growth factor receptor 2-negative breast cancer patients who received neoadjuvant chemotherapy

 

NLR < 2.74 (N = 825)

NLR ≥ 2.74 (N = 272)

Total (N = 1,097)

p-value

Age (median, range)

48 (20–84)

45 (22–76)

47 (20–84)

 < 0.001

Histologic type

   

0.407

IDC

771 (93.5%)

258 (94.9%)

1,029 (93.8%)

 

Others

54 (6.5%)

14 (5.1%)

68 (6.2%)

 

ER

   

0.067

Positive

483 (58.5%)

142 (52.2%)

625 (57.0%)

 

Negative

342 (41.5%)

130 (47.8%)

472 (43.0%)

 

PR

   

0.752

Positive

370 (44.8%)

119 (43.8%)

489 (44.6%)

 

Negative

455 (55.2%)

149 (56.3%)

608 (55.4%)

 

Subgroup

   

0.113

HR+HER2−

491 (59.5%)

147 (54.0%)

638 (58.2%)

 

TNBC

334 (40.5%)

125 (46.0%)

459 (41.8%)

 

Ki-67*

   

0.010

< 14

143 (34.7%)

34 (23.1%)

177 (31.7%)

 

≥ 14

269 (65.3%)

113 (76.9%)

382 (68.3%)

 

cT

   

0.025

1

125 (15.2%)

28 (10.3%)

153 (13.9%)

 

2

558 (67.6%)

181 (66.5%)

739 (67.4%)

 

3

142 (17.2%)

63 (23.2%)

205 (18.7%)

 

cN

   

0.444

Negative

128 (15.5%)

37 (13.6%)

165 (15.0%)

 

Positive

697 (84.5%)

235 (86.4%)

932 (85.0%)

 

pCR

   

0.033

No

635 (77.0%)

226 (83.1%)

861 (78.5%)

 

Yes

190 (23.0%)

46 (16.9%)

236 (21.5%)

 

Regimen

   

0.009

AC-T

661 (80.1%)

196 (72.1%)

857 (78.1%)

 

AC

26 (3.2%)

10 (3.7%)

36 (3.3%)

 

AT

113 (13.7%)

47 (17.3%)

160 (14.6%)

 

Others

25 (3.0%)

19 (7.0%)

44 (4.0%)

 
  1. NLR neutrophil to lymphocyte ratio, ER estrogen receptor, PR progesterone receptor, cT clinical T stage, cN clinical N stage, pCR pathologic complete response, AC-T doxorubicin and cyclophosphamide followed by taxane, AC doxorubicin and cyclophosphamide, AT doxorubicin and taxane.
  2. *Missing values.
  3. Others: cyclophosphamide, doxorubicin, 5-fluorouracil (CAF); cyclophosphamide, methotrexate, 5-fluorouracil (CMF); taxane; taxane plus carboplatin.