Figure 2

Bacteroides decrease faecal LPS levels. (a) Twenty-five genera of the gut microbiota were ranked according to the importance of their contribution to faecal LPS levels, as determined by a random forest classifier. (b) Patients were divided into three groups according to the abundance of Bacteroides in the gut microbiota. The relative abundance of the top 25 genera are indicated. (c) A principal coordinate analysis was performed to compare the distribution of each genus in the gut microbiota. Only genera with larger weight on principal coordinate analysis are shown. (d) Relative abundance of Bacteroides (percentage of total gut bacteria) among three groups. (e) Spearman’s rank correlation coefficient was calculated between faecal LPS levels and relative abundance of Bacteroides. (f) Distribution of controls and patients with CAD or HF in each cluster. Data are shown as median ± interquartile range (25th–75th percentile) (d). CAD, coronary artery disease; EU, endotoxin units; HF, heart failure; LPS, lipopolysaccharide.