Figure 4
From: Reduction of focal sweating by lipid nanoparticle-delivered myricetin
Transappendageal delivery of M-LNP. Fluorescence microscopic images of porcine skin vertically cryosectioned after incubation with (a) NR solution (5 vol% DMSO in PBS) or (b) NR-LNP (scale bars, 100 μm; SC stratum corneum, E epidermis, D dermis, H hair follicle). Thickness between neighboring cryosections was 20 μm. Schematic representations of (c) transdermal delivery (transappendageal and transepidermal routes) and (d) sweating-inhibitory activity of M-LNPs deformed by non-specific esterase present in the skin applied with M-LNPs.
