Table 2 Results for rs10947231 and rs8192575 from discovery GWIS For FEV1/FVC, GWIS was performed on healthy individuals with 3,351,033 SNPs, and the genome-wide significant result are summarized. \({\upbeta }_{\mathrm{SNP}}\) and \({\upbeta }_{\mathrm{INT}}\) are the coefficients for the main SNP and interaction effects between SNP and pack-years of smoking, respectively. Overall effects indicate P values (PLR) for testing the null hypotheses \({\text{H}}_{0} :\beta_{SNP} = \beta_{SNP - pack\;years} = 0\) by F test.

From: Effect of 6p21 region on lung function is modified by smoking: a genome-wide interaction study

 

Data

Minor/Major alleles

MAF

P value for HWE

Missing rate

INFO†

\({\upbeta }_{\mathrm{SNP}}\)(SE)

PSNP

\({\upbeta }_{\mathrm{INT}}\)(SE)

PINT

Overall effects (PLR)

rs10947231 Chromosome (BP) 6(32,054,346)

Discovery

KARE

A/C

0.165

0.767

0.015

0.983

0.835

(0.13)

1.42 × 10–10

0.001

(0.007)

0.8417

2.23 × 10–12

Replication

GENIE

A/C

0.18

0.902

0

0.999

0.178

(0.198)

0.3678

0.026

(0.014)

0.0684

0.0698

 

ARIRANG

A/C

0.17

0.638

0.016

0.985

0.967

(0,473)

0.04151

− 0.056

(0.03)

0.0583

0.0714

rs8192575 Chromosome (BP) 6(32,166,384)

Discovery

KARE

G/C

0.15

0.549

0.027

0.976

0.821

(0.136)

1.77 × 10–9

− 0.02

(0.008)

0.0165

1.18 × 10–8

Replication

GENIE

G/C

0.163

0.425

0

1

0.533

(0.21)

0.0113

− 0.031

(0.016)

0.0454

0.0173

 

ARIRANG

G/C

0.176

0.357

0.006

0.996

0.702

(0.484)

0.1471

− 0.067

(0.027)

0.0131

0.0457

  1. BP physical position (Based on hg19), MAF minor allele frequencies, HWE Hardy–Weinberg equilibrium, SE standard error.
  2. †INFO is the imputation quality metric obtained from IMPUTE2.
Back to article page