Figure 1

Dose-dependent effects of the A391T variant on regional T2w/T1w ratio. (a) Representative maps of the T2w/T1w ratio in CT and TT carriers overlaid on CC controls where ratio is either increased or decreased with a p value of < 0.05 on a pixel-by-pixel basis via student’s t-test. Heat map corresponds to the direction of change of the T2w/T1w ratio relative to the CC group, with yellow/orange representing an increase and blue representing a decrease. (b) Quantification of ROIs including globus pallidus (GPi), lateral putamen (LPut), and substantia nigra (SN) based on rs13107325 genotype, compared using post-hoc Dunnett’s test. Data points are shown for each individual, with the black horizontal line representing mean for each genotype. CC (white circles) n = 46, CT (gray circles) n = 44, TT (black circles) n = 43.