Table 3 Differences in MR imaging findings between MMA patients with different clinical subgroups.

From: Brain MRI features of methylmalonic acidemia in children: the relationship between neuropsychological scores and MRI findings

MR imaging finding

The group by clinical screening (N, %)

χ2

P

SS (18)

NS(19)

Cerebral sulcus widened

9 (50.0)

8 (42.1)

0.232

0.746

Cerebellar atrophy

5 (27.8)

2 (10.5)

1.793

0.232

Brainstem thinning

4 (22.2)

1 (5.3)

2.275

0.180

Corpus callosum thinning

8 (44.4)

7 (36.8)

0.222

0.743

Cortical atrophy (sulcal widening)

9 (50.0)

6 (31.6)

1.301

0.325

Ventricular dilation (0–3 grade)

0

12 (66.7)

14 (73.7)

1.128

0.770

Mild

1 (5.6)

2 (10.5)

  

Moderate

1 (5.6)

1 (5.3)

  

Severe

4 (22.2)

2 (10.5)

  

Subcortical white matter change

7 (38.9)

7 (36.8)

0.016

0.898

Periventricular white matter change

0

4 (22.2)

4 (21.1)

1.347

0.718

Mild

12 (66.7)

13 (68.4)

  

Moderate

1 (5.6)

2 (10.5)

  

Severe

1 (5.6)

0

  

Internal capsule change

2 (11.1)

2 (10.5)

0.003

0.954

Signal change consistent with focal infarct

0

3 (15.8)

3.093

0.051

Abnormal signal in basal ganglia

1

0