Table 5 Differences in imaging findings between MMA patients with different developmental quotient subgroups.

From: Brain MRI features of methylmalonic acidemia in children: the relationship between neuropsychological scores and MRI findings

MR imaging finding

The group by developmental quotient (N, %)

χ2

P

Normal (11)

Lower (26)

Cerebral sulcus widened

4 (36.4)

13 (50.0)

0.579

0.447

Cerebellar atrophy

1 (9.1)

6 (23.1)

0.986

0.321

Brainstem thinning

1 (9.1)

4 (15.4)

0.262

0.609

Corpus callosum thinning

0

15 (57.7)

10.673

0.001

Cortical atrophy (sulcal widening)

2 (18.2)

13 (50.0)

3.246

0.052

Ventricular dilation (0–3 grade)

0–mild

11 (100)

18 (69.2)

5.366

0.049a

Moderate–severe

0

8 (30.8)

4.318

0.038a

Subcortical white matter change

1 (9.1)

13 (50.0)

5.500

0.019

Periventricular white matter change

0

3 (27.3)

5 (19.2)

1.807

0.730a

Mild

9 (81.8)

16 (61.5)

  

Moderate

0

3 (11.5)

  

Severe

0

1 (3.8)

  

Internal capsule change

0

4 (15.4)

1.897

0.168

Signal change consistent with focal infarct

1 (9.1)

2 (7.7)

0.020

0.887

Abnormal signal in basal ganglia

0

1 (3.8)

 
  1. aFisher's exact probability method is used.